![]() Since starting his independent career, Dr. These research outcomes have provided new inspirations and new methodologies for epigenetic research. The laboratory is adept at comprehensively utilizing biochemistry, molecular biology, cell biology, and biophysics to reveal the biological significance of histone post-translational modifications and their regulatory mechanisms. Li's research group is committed to research related to epigenetics, chemical proteomics, and medicinal chemistry. Xiang David Li, member of the Hong Kong Young Academy of Sciences (YASHK), is a tenured professor of the Department of Chemistry at the University of Hong Kong. Protein target identification of small molecules (i.e., drug target I.D.) and mapping drug binding sites.ĭr. Chemical inhibitors of epigenetic ‘readers’, ‘erasers’ and ‘writers’Ĥ. Chemical approaches to examine posttranslational modifications (PTMs) and PTM-mediated protein-protein interactionsģ. Regulation and function of histone modificationsĢ. ![]() And, although we loaded publications into it, they won't appear there until you claim it.1. Did you remember to claim your ORCID account? If not, you cannot use it with publishers.Similar for "Professional Qualifications".Please send to us at address below, and we will add a biography section to your page.If you want them to appear here, please write to the address below, and tell us! Some people did not want them, so we turned it off.Want your "Invited Lectures & Keynote Speeches" to appear? You may log into your ResearcherPage with your HKU Portal, and use the "Manage Publications" entry on the green left side menu, to unlink publications from your ResearcherPage, or, select a few to appear in a new box, "Selected Publications".Want to make a "Selected Publications" section? You may google for HKU Libraries can instruct on Endnote, either in class or one on one, If you are NOT going to enter publication data into ROS, or if you have publications from before your time at HKU, please put them into an EndNote file and send to us, It will allow us to enter in batch.It will help us match on outside sources, dedup, and bring in cleaner data than ROS supplies. When entering data into ROS, please remember to include the DOI or ISBN. If you have entered, or are going to enter data into ROS, we do not want to enter them manually into the Hub, as it will create duplicates. We receive data from HKU's Research Output System (ROS), after you or your people enter data there.If you do not see your publications here, please note: Our findings might also reveal novel strategies for developing antiviral and immunomodulatory agents including vaccine adjuvants. We aspire to substantially advance current understanding of viral and cellular regulators of innate antiviral response. Particularly, cellular machinery to sense viral nucleic acids, features of viral nucleic acids being sensed, and enzymes that cleave the second messenger will be dissected. Novel cellular and viral regulatory factors that govern antiviral response will be identified and characterized. One major area of my current research is in the regulatory mechanism of innate antiviral response. In 2011, we found that the virus sensor RIG-I needs an RNA-binding protein partner called PACT to initiate and sustain host antiviral defense. Our work in 2008 revealed how Epstein-Barr virus uses a viral small RNA molecule to promote the survival of tumor cells in nasopharyngeal carcinoma. In 2006, my group characterized another cellular protein, which is also crippled by Tax to give rise to abnormal numbers of chromosomes in leukemic cells. In my study of a viral oncogenic protein named Tax produced by human T-cell leukemia virus type 1, which causes a highly lethal blood cancer known as adult T-cell leukemia, I identified in 1998 a cellular protein named MAD1, a key component of a cell cycle checkpoint that guard against abnormal division of cells. We use a combination of biochemical and genetic approaches to conduct basic research in molecular virology and oncology with the aim of applying the knowledge gained to prevention and control of human diseases. My research is focusing primarily on the molecular basis of viral diseases and cancer. I joined the University of Hong Kong in 1999 and am now a Professor in the Department of Biochemistry. Kuan-Teh Jeang at the National Institute of Allergy and Infectious Diseases in 1994-1999. I received postdoctoral training with Dr. Yun-De Hou at the State Key Laboratory for Molecular Virology in Beijing in 1986-1991. ![]()
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